T. Senda

Native spike flexibility revealed by BSL3 Cryo-ET of active SARS-CoV-2 virions

This study uses cryo-ET to analyze native, active SARS-CoV-2 virions, revealing a transient open-trimer prefusion state and hidden spike flexibility with implications for vaccine design.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation

This study identifies three distinct effector pathways regulated by Apc in murine intestinal epithelia, each contributing to normal tissue homeostasis and tumorigenesis when disrupted by oncogenic Apc mutations.

Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

Crystallographic and cryogenic electron microscopic structures and enzymatic characterization of sulfur oxygenase reductase from Sulfurisphaera tokodaii

This paper reports the biochemical and structural characterization of SOR from Sulfurisphaera tokodaii, presenting high-resolution crystal and cryo-EM structures and analyzing the role of iron and cysteines in catalysis.

An integrated approach unravels a crucial structural property for the function of the insect steroidogenic Halloween protein Noppera-bo

This paper determines the structure of the insect steroidogenic Halloween protein Noppera-bo and identifies a conserved residue critical for its function.

Serial femtosecond X-ray diffraction of HIV-1 Gag MA-IP6 microcrystals at ambient temperature

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

A single-cell reference map for human blood and tissue T cell activation reveals functional states in health and disease