Author

Y. M. Chook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

H. Y. J. Fung· 3 shared J. Jiou· 3 shared J. M. Shaffer· 2 shared S. D'Arcy· 2 shared A. B. Neisman· 1 shared A. J. Gonzalez· 1 shared B. D. Freibaum· 1 shared C. Brautigam· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

H. Y. J. Fung

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus

H. Y. J. Fung, A. B. Neisman, N. E. Bernardes, J. Jiou, Y. M. Chook

This study reveals how Kap114 and Nap1 co-chaperone H2A-H2B during nuclear import and nucleosome assembly through structural and biochemical analyses.

bioRxiv · May 9, 2023Biochemistry

Molecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9

J. M. Shaffer, J. Jiou, K. Tripathi, O. S. Olaluwoye, H. Y. J. Fung, Y. M. Chook, S. D'Arcy

This paper defines the molecular mechanism by which RanGTP activates Imp9 to facilitate nucleosome assembly by releasing H2A-H2B from the complex.

bioRxiv · Jan 27, 2023 · PreprintBiophysics

A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 is linked to neurodevelopmental disorders

A. J. Gonzalez, H. J. Kim, B. D. Freibaum, C. Brautigam, J. P. Taylor, Y. M. Chook

This study identifies a new Karyopherin-β2 binding epitope in HNRNPH2 linked to neurodevelopmental disorders, explaining cytoplasmic accumulation due to nuclear import defects.

bioRxiv · Jan 20, 2023Biophysics

Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP·Kap114·H2A-H2B complex

J. Jiou, J. M. Shaffer, N. Bernardes, H. Y. J. Fung, J. Kikumoto Dias, S. D'Arcy, Y. M. Chook

This paper reveals the structure of the RanGTP·Kap114·H2A-H2B complex and explains how RanGTP primes H2A-H2B release for nucleosome assembly.

bioRxiv · Nov 22, 2022Biochemistry