A. Subramanian

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

RORγt+ B cells express proinflammatory cytokines and promote allo- and auto- immunity

The paper identifies TIM-4+ B cells that express proinflammatory cytokines like IL-17A and promote auto- and allo-immunity by preventing their conversion into regulatory B cells.

A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

This paper identifies SidI, a Legionella toxin that mimics tRNA, glycosylates the translation machinery, and triggers a ribotoxic stress response leading to cell death.

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

{-}Multivariable Association Discovery in Population-scale Meta-omics Studies

This paper introduces MaAsLin 2, a method for analyzing multivariable associations in microbial multi-omics data, and applies it to reveal new insights into inflammatory bowel disease.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

Alternative polyadenylation is a determinant of oncogenic Ras function

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

Non-oncology drugs are a source of previously unappreciated anti-cancer activity

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.