Author

N. T. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. G. Kirsch· 6 shared L. Luo· 6 shared Y. Ma· 5 shared K. Deland· 4 shared C. Su· 3 shared O. J. Becher· 3 shared A. J. Wisdom· 2 shared C. E. Stewart· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersCancer Biology

D. G. Kirsch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

C. Su, C. L. Kent, M. Pierpoint, W. Floyd, L. Luo, N. T. Williams, Y. Ma, B. Peng, A. L. Lazarides, A. Subramanian, J. E. Himes, V. M. Perez, R. D. Hernansaiz-Ballesteros, K. E. Roche, J. L. Modliszewski, , D. G. Kirsch

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

bioRxiv · Jan 3, 2024 · PreprintCancer Biology

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

A. Mangoli, S. Wu, H. Q. Liu, M. Aksu, V. J. Jain, B. E. Foreman, J. A. Regal, L. B. Weidenhammer, C. E. Stewart, M. E. Guerra Garcia, E. Hocke, K. Abramson, N. T. Williams, L. Luo, K. Deland, , Z. J. Reitman

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

bioRxiv · Oct 18, 2023Cancer Biology

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

W. Floyd, M. Pierpoint, C. Su, L. Luo, K. Deland, A. J. Wisdom, D. Zhu, Y. Ma, S. B. DeWitt, N. T. Williams, J. A. Somarelli, D. L. Corcoran, W. C. Eward, D. M. Cardona, D. G. Kirsch

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

Journal of Clinical Investigation · Jul 3, 2023Peer-reviewedCancer Biology

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

A. R. Daniel, C.-L. Lee, C. Su, N. T. Williams, Z. Li, J. Huang, O. Lopez, L. Luo, Y. Ma, L. D. S. Campos, S. R. Selitsky, J. L. Modliszewski, S. Liu, Y. M. Mowery, D. M. Cardona, D. G. Kirsch

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

bioRxiv · Oct 28, 2022Cancer Biology

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

C. E. Stewart, M. E. Guerra Garcia, L. Luo, N. T. Williams, Y. Ma, J. A. Regal, D. Ghosh, P. Sansone, M. Oldham, K. Deland, O. J. Becher, D. G. Kirsch, Z. J. Reitman

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

bioRxiv · Aug 5, 2022Cancer Biology

Tumor genotype dictates radiosensitization after Atm deletion in brainstem gliomas

K. Deland, B. F. Starr, J. S. Mercer, J. Byemerwa, D. M. Crabtree, N. T. Williams, L. Luo, Y. Ma, M. Chen, O. J. Becher, D. G. Kirsch

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.

bioRxiv · Aug 24, 2020Cancer Biology