Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition
H. Shimano, Y. Nakagawa, Y. Yunong Wang, S.-i. Han, K. Okuda, A. Oishi, Y. Yagishita, K. Kumagai, H. Ohno, Y. Osaki, Y. Mizunoe, Y. Murayama, H. Iwasaki, M. Konishi, N. Itoh, , M. Araki
This study shows CREB3L3 protects against atherosclerosis by inhibiting SREBP activity through competitive antagonism, reducing lipogenic and cholesterogenic gene expression.
bioRxiv · Apr 29, 2020Physiology