Author

Y. Murayama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein structure prediction· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S.-i. Sekine· 3 shared H. Ehara· 2 shared M. Aoki· 2 shared M. Goto· 2 shared T. Yokoyama· 2 shared A. Li· 1 shared A. Nagao· 1 shared A. Oishi· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

S.-i. Sekine

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex

T. Yanagisawa, Y. Murayama, H. Ehara, M. Goto, M. Aoki, S.-i. Sekine

The paper reports cryo-EM structures of the Rat1-Rai1-Rtt103 complex and RNAPII complexes from yeast, revealing the mechanism of mRNA transcription termination by Rat1 exonuclease.

bioRxiv · Mar 28, 2024Biochemistry

Structural insight into bacterial co-transcriptional translation initiation

T. Yokoyama, Y. Murayama, T. Uchikubo-Kamo, Y. Tomabechi, A. Nagao, T. Suzuki, M. Shirouzu, S.-i. Sekine

The paper reports cryo-EM structures of the translation initiation complex assembled on transcribing RNA polymerase, showing how mRNA is protected during co-transcriptional translation initiation.

bioRxiv · Mar 19, 2024 · PreprintBiochemistry

Molecular mechanism of parental H3/H4 recycling at a replication fork

F. Nagae, Y. Murayama, T. Terakawa

This study uses molecular dynamics simulations to investigate how H3/H4 tetramers are recycled during DNA replication in yeast, revealing pathways and regulatory factors involved in strand-specific recycling.

bioRxiv · Mar 7, 2024Biophysics

Liquid plug propagation in computer-controlled microfluidic airway-on-a-chip with semi-circular microchannels

H. Viola, V. Vasani, K. Washington, J. H. Lee, C. Selva, A. Li, C. J. Llorente, Y. Murayama, J. B. Grotberg, F. Romano, S. Takayama

This paper presents a lung-on-a-chip device that enables systematic study of liquid plug dynamics in distal airways, showing effects of surfactant, viscosity, and channel geometry on plug propagation and epithelial cell injury.

bioRxiv · May 24, 2023Bioengineering

Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase

Y. Murayama, H. Ehara, M. Goto, M. Aoki, T. Yokoyama, S.-i. Sekine

The paper reports the cryo-EM structure of RNA polymerase engaged with Rho, revealing how Rho interacts with RNAP to mediate transcription termination.

bioRxiv · Sep 2, 2022Biochemistry

Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition

H. Shimano, Y. Nakagawa, Y. Yunong Wang, S.-i. Han, K. Okuda, A. Oishi, Y. Yagishita, K. Kumagai, H. Ohno, Y. Osaki, Y. Mizunoe, Y. Murayama, H. Iwasaki, M. Konishi, N. Itoh, , M. Araki

This study shows CREB3L3 protects against atherosclerosis by inhibiting SREBP activity through competitive antagonism, reducing lipogenic and cholesterogenic gene expression.

bioRxiv · Apr 29, 2020Physiology