The human liver microenvironment shapes the homing and function of CD4+ T-cell populations
B. G. Wiggins, L. J. Pallett, X. Li, S. P. Davies, O. E. Amin, U. S. Gill, A. M. Patel, K. Aliazis, Y. S. Liu, G. M. Reynolds, G. Hirschfield, P. F. Kennedy, Y. Huang, M. M. Maini, Z. Stamataki
This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.
bioRxiv · Aug 3, 2020Immunology