Author

Z. Stamataki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Immunology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Assay:structural biology· 2

Frequent Co-Authors

S. P. Davies· 4 shared H. J. Hill· 3 shared A. Arvaniti· 1 shared A. Bacon· 1 shared A. Culhane· 1 shared A. Garai· 1 shared A. J. Thompson· 1 shared A. K. Linnemann· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiochemistry

S. P. Davies

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

M. Pugh, E. Fennel, C. I. Leahy, T. Perry, B. Hargitai, T. Marton, K. J. Hunter, G. Halford, H. O. Yilmaz, Z. Stamataki, G. Reynolds, H. J. Hill, B. E. Willcox, N. M. Steven, C. A. Thornton, , G. S. Taylor

The paper uses multi-omic spatial profiling to show that SARS-CoV-2 infection in the placenta leads to a distinct immune signature with PDL1-expressing macrophages and T-cell exclusion.

bioRxiv · Nov 14, 2022 · PreprintImmunology

A cell-based, spike protein binding assay highlights differences in antibody neutralising capacity for SARS-CoV-2 variants

N. Harrison, L. Richardson, C. Pallini, I. Morano, E. Jinks, J. Cowley, H. Chan, H. Hill, C. Matas de las Heras, A. Teodosio, A. S. Lavado, T. R. Dafforn, D. K. Grammatopoulos, J. Gordon, C. A. Brady, , O. S. Qureshi

The paper develops a cell-based ACE2/spike protein binding assay to assess antibody neutralising capacity against SARS-CoV-2 variants and shows differential blocking activity of monoclonal antibodies.

bioRxiv · Jun 24, 2022 · PreprintCell Biology

Supramolecular cylinders target bulge structures in the 5-prime UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

L. Melidis, H. J. Hill, N. J. Coltman, S. P. Davies, K. Winczura, T. Chauhan, J. S. Craig, A. Garai, C. A. J. Hooper, R. T. Egan, J. A. McKeating, N. J. Hodges, Z. Stamataki, P. Grzechnik, M. J. Hannon

The paper models the 5' UTR structure of SARS-CoV-2 and shows supramolecular cylinders bind to a bulge and junction, inhibiting viral replication.

bioRxiv · Mar 30, 2021Biochemistry

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models

S. P. Davies, C. J. Mycroft-West, I. Pagani, H. J. Hill, Y.-H. Chen, R. T. Karlsson, I. Bagdonaite, S. E. Guimond, Z. Stamataki, M. A. Lima, J. E. Turnbull, Z. Yang, E. E. Vicenzi, M. A. Skidmore, F. Khanim, A. Richardson

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

bioRxiv · Jan 10, 2021Pharmacology & Toxicology

Formulation of a composite nasal spray enabling enhanced surface coverage and prophylaxis of SARS-COV-2

R. J. A. Moakes, S. P. Davies, Z. Stamataki, L. M. Grover

This paper develops a nasal spray formulation with antiviral properties to prevent SARS-CoV-2 infection and transmission by enhancing surface coverage through mucoadhesive polymers.

bioRxiv · Nov 18, 2020Bioengineering

The human liver microenvironment shapes the homing and function of CD4+ T-cell populations

B. G. Wiggins, L. J. Pallett, X. Li, S. P. Davies, O. E. Amin, U. S. Gill, A. M. Patel, K. Aliazis, Y. S. Liu, G. M. Reynolds, G. Hirschfield, P. F. Kennedy, Y. Huang, M. M. Maini, Z. Stamataki

This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.

bioRxiv · Aug 3, 2020Immunology

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

L. F. Sobala, P. Z. Fernandes, Z. Hakki, A. J. Thompson, J. D. Howe, M. Hill, N. Zitzmann, S. Davies, Z. Stamataki, T. D. Butters, D. S. Alonzi, S. J. Williams, G. J. Davies

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

bioRxiv · Jun 30, 2020Biochemistry

LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

J. Ast, A. Arvaniti, N. H. F. Fine, D. Nasteska, F. B. Ashford, Z. Stamataki, Z. Koszegi, A. Bacon, S. Trapp, B. J. Jones, B. Hastoy, A. Tomas, C. Reissaus, A. K. Linnemann, E. D'Este, , D. J. Hodson

The paper introduces LUXendin peptides that label and visualize endogenous GLP1R with high specificity, revealing receptor organization and dynamics.

bioRxiv · May 8, 2019Cell Biology