Author

S. P. Davies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Z. Stamataki· 4 shared H. J. Hill· 2 shared A. Garai· 1 shared A. M. Patel· 1 shared A. Richardson· 1 shared B. G. Wiggins· 1 shared C. A. J. Hooper· 1 shared C. J. Mycroft-West· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

Z. Stamataki

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Author profile →

4 papers

Recent·Most cited

Supramolecular cylinders target bulge structures in the 5-prime UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

L. Melidis, H. J. Hill, N. J. Coltman, S. P. Davies, K. Winczura, T. Chauhan, J. S. Craig, A. Garai, C. A. J. Hooper, R. T. Egan, J. A. McKeating, N. J. Hodges, Z. Stamataki, P. Grzechnik, M. J. Hannon

The paper models the 5' UTR structure of SARS-CoV-2 and shows supramolecular cylinders bind to a bulge and junction, inhibiting viral replication.

bioRxiv · Mar 30, 2021Biochemistry

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models

S. P. Davies, C. J. Mycroft-West, I. Pagani, H. J. Hill, Y.-H. Chen, R. T. Karlsson, I. Bagdonaite, S. E. Guimond, Z. Stamataki, M. A. Lima, J. E. Turnbull, Z. Yang, E. E. Vicenzi, M. A. Skidmore, F. Khanim, A. Richardson

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

bioRxiv · Jan 10, 2021Pharmacology & Toxicology

Formulation of a composite nasal spray enabling enhanced surface coverage and prophylaxis of SARS-COV-2

R. J. A. Moakes, S. P. Davies, Z. Stamataki, L. M. Grover

This paper develops a nasal spray formulation with antiviral properties to prevent SARS-CoV-2 infection and transmission by enhancing surface coverage through mucoadhesive polymers.

bioRxiv · Nov 18, 2020Bioengineering

The human liver microenvironment shapes the homing and function of CD4+ T-cell populations

B. G. Wiggins, L. J. Pallett, X. Li, S. P. Davies, O. E. Amin, U. S. Gill, A. M. Patel, K. Aliazis, Y. S. Liu, G. M. Reynolds, G. Hirschfield, P. F. Kennedy, Y. Huang, M. M. Maini, Z. Stamataki

This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.

bioRxiv · Aug 3, 2020Immunology