Author

Y. Sancak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. J. Pradhan· 1 shared A. L. Markhard· 1 shared D. K. Schweppe· 1 shared D. M. Shechner· 1 shared D. V. Rusnac· 1 shared F. Bradford· 1 shared G. E. Atilla-Gokcumen· 1 shared G. M. Otto· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

A. J. Pradhan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

High-Throughput Identification of Calcium Regulated Proteins Across Diverse Proteomes

T. M. Locke, R. Fields, H. Gizinski, G. M. Otto, D. M. Shechner, M. D. Berg, J. Villen, Y. Sancak, D. K. Schweppe

The paper identifies 2884 calcium-regulated proteins across human, mouse, and yeast proteomes using thermostability assays and reveals novel calcium engagement in metabolic enzymes and the spliceosome.

bioRxiv · Jan 18, 2024Cell Biology

Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells.

J. J. Vicente, K. Khan, G. Tillinghast, J. L. McFaline-Figueroa, Y. Sancak, N. Stella

The paper identifies ST-401 as an interphase-specific killer of cancer cells that prevents the formation of polyploid giant cancer cells.

bioRxiv · Aug 31, 2023 · PreprintCell Biology

Acylation of MLKL impacts its function in necroptosis

A. J. Pradhan, S. Chitkara, R. Ramirez, V. Monje-Galvan, Y. Sancak, G. E. Atilla-Gokcumen

This study identifies acylation sites on MLKL and shows that acylation at specific cysteines affects its membrane interaction and necroptosis activity.

bioRxiv · Aug 19, 2023Biochemistry

Mathematical modeling and biochemical analysis support partially ordered CaM-MLCK binding

M. J. MacEwen, D. V. Rusnac, H. Ermias, T. L. M. Locke, H. E. Gizinski, J. P. Dexter, Y. Sancak

The paper uses mathematical models and biochemical experiments to determine that CaM binds MLCK in a partially ordered manner.

bioRxiv · Jun 8, 2022Biochemistry

Molecular basis of EMRE-dependence of the human mitochondrial calcium uniporter

M. J. S. MacEwen, A. L. Markhard, M. Bozbeyoglu, F. Bradford, O. Goldberger, V. K. Mootha, Y. Sancak

The paper identifies an EMRE-dependence domain in human MCU that enables calcium conductance, revealing how EMRE stabilizes this domain for channel function.

bioRxiv · May 14, 2019 · PreprintBiochemistry