Author

J. Villen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Organism:yeast· 2

Frequent Co-Authors

M. J. MacCoss· 3 shared D. J. Marcinek· 2 shared M. D. Campbell· 2 shared M. Martin-Perez· 2 shared W.-J. Qian· 2 shared A. Folch· 1 shared A. Locke· 1 shared B. C. Searle· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersPhysiology

M. J. MacCoss

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

L. F. Horowitz, R. A. Rodriguez-Mias, M. Chang, S. Zhu, Y. Tang, A. Locke, N. R. Gottshall, I. Stepanov, C. Stiles, M. Yeung, T. N. Nguyen, E. J. Lockhart, C. Ahls, E. Wayne, W. Wei, , A. Folch

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

bioRxiv · Mar 22, 2024 · PreprintCancer Biology

High-Throughput Identification of Calcium Regulated Proteins Across Diverse Proteomes

T. M. Locke, R. Fields, H. Gizinski, G. M. Otto, D. M. Shechner, M. D. Berg, J. Villen, Y. Sancak, D. K. Schweppe

The paper identifies 2884 calcium-regulated proteins across human, mouse, and yeast proteomes using thermostability assays and reveals novel calcium engagement in metabolic enzymes and the spliceosome.

bioRxiv · Jan 18, 2024Cell Biology

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Elamipretide (SS-31) Treatment Attenuates Age-Associated Post-Translational Modifications of Heart Proteins

J. A. Whitson, M. Martin-Perez, T. Zhang, M. J. Gaffrey, G. E. Merrihew, E. Huang, C. C. White, T. J. Kavanagh, W.-J. Qian, M. D. Campbell, M. J. MacCoss, D. J. Marcinek, J. Villen, P. S. Rabinovitch

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

bioRxiv · Aug 6, 2021Cell Biology

Comprehensive peptide quantification for data independent acquisition mass spectrometry using chromatogram libraries

B. C. Searle, L. K. Pino, J. D. Egertson, Y. S. Ting, R. T. Lawrence, J. Villen, M. J. MacCoss

The paper introduces a workflow and software tool, EncyclopeDIA, to improve peptide quantification in DIA mass spectrometry by using chromatogram libraries calibrated to specific instruments.

bioRxiv · Mar 7, 2018Biochemistry