Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells
L. A. Herr, G. J. Fiala, A.-M. Schaffer, K. Raute, R. M.-H. Velasco Cardenas, J. F. Hummel, K. Ebert, Y. Tanriver, S. Minguet, W. W. Schamel
This study shows Kidins220 modulates TCR signaling in thymic and splenic iNKT cells, promoting development in the thymus by reducing TCR signals but enhancing TCR signals in the periphery.
bioRxiv · Apr 5, 2022 · PreprintImmunology