C. S. Falk

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

Donor tissue-resident memory-like T and NK cells generate a transient peripheral chimerism in lung transplant recipients, potentially protective from chronic lung allograft dysfunction

Donor TRM-like T and NK cells create a temporary chimerism in lung transplant recipients, possibly reducing the risk of chronic lung allograft dysfunction.

Triple COVID-19 vaccination induces humoral and cellular immunity to SARS-CoV-2 with cross-recognition of the Omicron variant and IgA secretion

This study shows that triple COVID-19 vaccination increases IgG levels, boosts antibody inhibitory capacity against variants, and induces T cell responses, with Omicron breakthrough infections adding new variant-specific antibodies.

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development

This study investigates how influenza A virus-induced thymus atrophy affects Treg cell development and shows a relative increase in tTreg cells with reduced TCR diversity.