Transcription regulation of SARS-CoV-2 receptor ACE2 by Sp1: a potential therapeutic target
H. Han, R.-H. Luo, X.-Y. Long, L.-Q. Wang, Q. Zhu, X.-Y. Tang, R. Zhu, Y.-C. Ma, Y.-T. Zheng, C.-g. Zou
This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.
bioRxiv · Feb 14, 2023Microbiology