Author

Y.-T. Zheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Organism:non-human primate· 3 Assay:proteomics· 3 Organism:rat· 3 Organism:human· 2

Frequent Co-Authors

J.-B. Han· 4 shared T.-Z. Song· 3 shared D.-D. Yu· 2 shared F.-L. Liu· 2 shared J. Sun· 2 shared J. Zhao· 2 shared X. Jin· 2 shared X. Li· 2 shared

Activity by Year

2021-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

J.-B. Han

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Transcription regulation of SARS-CoV-2 receptor ACE2 by Sp1: a potential therapeutic target

H. Han, R.-H. Luo, X.-Y. Long, L.-Q. Wang, Q. Zhu, X.-Y. Tang, R. Zhu, Y.-C. Ma, Y.-T. Zheng, C.-g. Zou

This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.

bioRxiv · Feb 14, 2023Microbiology

SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury

M.-L. Wu, F.-L. Liu, J. Sun, X. Li, X.-Y. He, H.-Y. Zheng, R.-J. Pei, H. Sun, Y.-H. Zhou, Q.-H. Yan, C.-X. Wu, L. Chen, G.-Y. Yu, J. Chang, X. Jin, , J.-H. Wang

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

bioRxiv · Jun 24, 2021Microbiology

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

S. Sun, Y. Cai, T.-Z. Song, Y. Pu, L. Cheng, H. Xu, C. Meng, Y. Lin, J. Sun, S. Zhang, Y. Gao, J.-B. Han, X.-L. Feng, D.-D. Yu, Y. Zhu, , H. Peng

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

bioRxiv · May 12, 2021Immunology

Homo-harringtonine (HHT) - A highly effective drug against coronaviruses and the potential for large-scale clinical applications

H.-J. Wen, P. Lin, G.-X. Zhong, Z.-C. Xu, L. Shuai, Z.-Y. Wen, C. Wang, X. Cao, W.-B. He, J. Feng, Q.-C. Cai, H.-J. Ma, S.-J. Wu, G.-D. Wang, X.-M. Lyu, , C.-I. Wu

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

bioRxiv · Apr 16, 2021 · PreprintMicrobiology

A recombinant receptor-binding domain in trimeric form generates completely protective immunity against SARS-CoV-2 infection in nonhuman primates

L. Yang, D. Tian, J.-b. Han, W. Fan, Y. Zhang, Y. Li, W. Sun, Y. Wei, X. Tian, D.-d. Yu, X.-l. Feng, G. Cheng, Y.-t. Zheng, Y. Bi, W. Liu

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

bioRxiv · Mar 30, 2021Immunology

A tandem-repeat dimeric RBD protein-based COVID-19 vaccine ZF2001 protects mice and nonhuman primates

Y. An, S. Li, X. Jin, J.-B. Han, K. Xu, S. Xu, Y. Han, C. Liu, T. Zheng, M. Liu, M. Yang, T.-z. Song, B. Huang, L. Zhao, W. Wang, , G. F. Gao

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

bioRxiv · Mar 11, 2021Immunology

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

J. G. Liang, D. Su, T.-Z. Song, Y. Zeng, W. Huang, J. Wu, R. Xu, P. Luo, X. Yang, X. Zhang, S. Luo, Y. Liang, X. Li, J. Huang, Q. Wang, , P. Liang

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Nature Communications · Mar 1, 2021Peer-reviewedImmunology