Spatial analysis reveals the evolving organization of low-grade and high-grade IDH-mutant glioma
Rouven Hoefflin, Alissa Greenwald, Noam Galili Darnell, Christopher Mount, Yali Tiomkin, Dor Simkin, Angelica Brooke Patterson, L. Nicolas Gonzalez Castro, Inna Goliand, Ofra Golani, Kevin Joseph, Jürgen Beck, Vidhya Madapusi Ravi, Merav Kedmi, Hadas Keren‐Shaul, , Itay Tirosh
This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.
bioRxiv · Mar 13, 2026 · PreprintCancer Biology