Kevin Joseph

This study shows riboflavin-sensitized UVA crosslinking increases the mechanical strength of bovine dura mater in a dose-dependent manner.

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

This study identifies a conserved ECM regulatory axis linking traumatic brain injury, spinal cord injury, and neural implant-induced injury through transcriptomic analysis, highlighting HA-DAMP signaling as a potential biomarker for monitoring implant biocompatibility.

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

The paper investigates how hypoxia and acidosis influence myeloid cell responses in glioblastoma, revealing distinct metabolic adaptations in macrophages versus microglia.

This study identifies an iron-associated mesenchymal subpopulation in GBM that drives invasion and is linked to poor patient survival.

This study characterizes the transcriptional response of glial cells to chronic implantation of flexible microprobes over 18 weeks, showing initial activation and eventual partial normalization.

SPATA bundles spatial transcriptomics analysis: spatially resolved expression, how transcriptional programs shift by region, and expression changes along spatial trajectories.

The paper quantifies how blanking during electrical stimulation affects spike train statistics, finding up to 27% spike loss at 130 Hz and 2 ms blanking window.

The paper compares electrophysiological properties of pyramidal neurons in epileptic and non-epileptic human neocortex, finding reduced excitability in epileptic neurons due to increased K+ channel activity.