Radiation therapy synergizes with mRNA vaccination to overcome microglia-mediated suppression of dendritic cell migration and T cell priming in glioblastoma
Amy J. Wisdom, Zachary J. Rogers, Fiona Chatterjee…·Stefani Spranger
Author
Broad InstituteORCID 0000-0003-1635-2492Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Amy J. Wisdom, Zachary J. Rogers, Fiona Chatterjee…·Stefani Spranger
Maolin Ge, Magdy Gohar, Consuelo Torrini…·Liron Bar‐Peled
The paper identifies oxidative protein states as drivers of metastatic fitness in lung cancer by linking ROS-regulated protein modifications to mitochondrial function and metastasis.
Rouven Hoefflin, Alissa Greenwald, Noam Galili Darnell…·Itay Tirosh
This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.
Shawn M. Gillespie, Yoon Seok Kim, Anna C. Geraghty…·Michelle Monje
This study identifies the NLGN3-CSPG4-PIEZO1 axis as a regulator of glial precursor cell state and glioma proliferation through mechanosensitive signaling.
Christopher Mount, Belgin Yalçın, Kennedy Cunliffe-Koehler…·Michelle Monje
The paper maps brain-wide afferent connectivity to oligodendrocyte precursor cells using monosynaptic tracing in adult mice, revealing extensive inputs from functionally interconnected cortical and thalamic regions.