Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy.
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Joanna Abi Rizk, Mingliang Zhang, Eleni Miliotou, Michael Cammer, Yan Deng, Valeria Mezzano, Mark Alu, Gyles Ward, Cynthia A. Loomis, Adriana Heguy, Feng‐Xia Liang, Eric M. Small, , Mario Delmar
This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.
Journal of the American Heart Association · Apr 28, 2026Peer-reviewedPhysiology