Disrupted TRiC allostery and conformational equilibrium by LCA-linked mutations: structural and functional insights
Qiaoyu Zhao, Caixuan Liu, Qing Zhang, Zuyang Li, Yanxing Wang, Xuehai Zhou, Xingyan Ye, Shanshan Wang, Yanke Wang, Wanying Jiang, Qianqian Song, Yao Cong
This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.
bioRxiv · Jan 23, 2026 · PreprintBiochemistry