Author

Wanying Jiang

University of Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Qianqian SongiD· 4 shared Qiaoyu ZhaoiD· 4 shared yanxing wangiD· 4 shared Yao CongiD· 3 shared Zuyang Li· 3 shared Qing ZhangiD· 2 shared Xiangyi ShiiD· 2 shared Xuehai ZhouiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersMolecular Biology

Qianqian SongORCID

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4 papers

Recent·Most cited

TRiC-assisted folding of class I HDAC family proteins regulated by distinct co-chaperone and cofactor networks

Zuyang Li, Qiaoyu Zhao, Wanying Jiang, Qianqian Song, Xuehai Zhou, Xiangyi Shi, Qing Zhang, yanxing wang, Yinghong Lin, Yue Yin, Pan Chen, Yao Cong

This study elucidates the TRiC-assisted folding of class I HDACs, revealing distinct co-chaperone and cofactor networks for HDAC1 and HDAC3, while HDAC8 folds independently.

Science Advances · Jul 15, 2026Peer-reviewedMolecular Biology

TRiC folds the giant ciliary protein IFT172 via a non-canonical open-state mechanism

Qiaoyu Zhao, Jiayi Li, Yujie Tong, Yurui Li, Wenyu Han, Zuyang Li, yanxing wang, Yue Yin, Jun Fang, Wanying Jiang, Qianqian Song, Shengyou Huang, Yidong Shen, Yao Cong

This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.

bioRxiv · Mar 31, 2026 · PreprintBiochemistry

Disrupted TRiC allostery and conformational equilibrium by LCA-linked mutations: structural and functional insights

Qiaoyu Zhao, Caixuan Liu, Qing Zhang, Zuyang Li, Yanxing Wang, Xuehai Zhou, Xingyan Ye, Shanshan Wang, Yanke Wang, Wanying Jiang, Qianqian Song, Yao Cong

This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.

bioRxiv · Jan 23, 2026 · PreprintBiochemistry

Development of immobilized antibody-based affinity grid strategy and application in on-grid purification of target proteins for high-resolution cryo-EM

Qiaoyu Zhao, Xiaoyu Hong, Yanxing Wang, Shaoning Zhang, Zhanyu Ding, Xueming Meng, Qianqian Song, Qin Hong, Wanying Jiang, Xiangyi Shi, Tianxun Cai, Cong Yao

The paper develops an immobilized antibody-based affinity grid strategy to improve cryo-EM sample preparation by enabling on-grid purification of target proteins and overcoming orientation issues.

bioRxiv · Jan 17, 2024 · PreprintMolecular Biology