Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors
Yichen Zhu, Xinyuan Shen, Yuning Chen, Nathan Ma, Catherine Zhang, Aiqi Zhao, Yanxin Tian, Shreya Gumate, Jie Huang, Siyu Lin, Aijun Wang, Vatche Garen Agopian, Yan-Ruide Li, Lili Yang
The paper shows microbial metabolites 5-OP-RU and 5-OE-RU activate MAIT cells to combat solid tumors by enhancing cytotoxicity, cytokine secretion, and reprogramming the tumor microenvironment.
bioRxiv · Jul 25, 2026 · PreprintCancer Biology