Author

Yichen Zhu

University of California, Los AngelesORCID 0000-0002-8772-2860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Yan-Ruide LiiD· 3 shared Lili YangiD· 2 shared Xinyuan SheniD· 2 shared Aijun WangiD· 1 shared Aiqi ZhaoiD· 1 shared B Y ZhangiD· 1 shared Catherine Zhang· 1 shared Citradewi SoemardyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

Yan-Ruide LiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering

Shubing Wang, Yan-Ruide Li, Qian Wang, Youcheng Yang, Xinyuan Shen, Haoran Li, Haochen Nan, Z J Chen, Yichen Zhu, B Y Zhang, Haoyan Ding, Jennifer Soto, Soomin Park, Yi Zheng, Xiangliang Huang, Debiao Li

A provenance-tracked multi-agent system curated 57 CAR-T patient scRNA-seq studies, generated reviewable hypotheses, and prioritized KLRC1/NKG2A, whose blockade improved CD8+ CAR-T antitumour activity in a Raji xenograft model.

bioRxiv · Jul 28, 2026 · PreprintBioengineering✦ In-depth digest

Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

Yichen Zhu, Xinyuan Shen, Yuning Chen, Nathan Ma, Catherine Zhang, Aiqi Zhao, Yanxin Tian, Shreya Gumate, Jie Huang, Siyu Lin, Aijun Wang, Vatche Garen Agopian, Yan-Ruide Li, Lili Yang

The paper shows microbial metabolites 5-OP-RU and 5-OE-RU activate MAIT cells to combat solid tumors by enhancing cytotoxicity, cytokine secretion, and reprogramming the tumor microenvironment.

bioRxiv · Jul 25, 2026 · PreprintCancer Biology

A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T Cells

Citradewi Soemardy, Yan-Ruide Li, Yichen Zhu, Lili Yang, Dino Di Carlo

This paper develops a nanovial-based platform to identify functional TCRs from unconventional T cells, isolating and validating five novel MAIT TCRs with antigen-specific activity.

bioRxiv · Aug 6, 2025 · PreprintBioengineering