Vatche Garen Agopian

The paper shows microbial metabolites 5-OP-RU and 5-OE-RU activate MAIT cells to combat solid tumors by enhancing cytotoxicity, cytokine secretion, and reprogramming the tumor microenvironment.

This study identifies galectin-1 as a prognostic biomarker for predicting thermal ablation response in hepatocellular carcinoma and shows that targeting Gal-1 enhances ablation efficacy by modulating glycolysis.

This paper introduces cfSNV, a somatic SNV caller for cfDNA that outperforms existing tools in detecting low-frequency mutations and applies it to immunotherapy prognosis in non-small-cell lung cancer.