Revisiting the need for mRNA nucleoside modification in CAR T cell engineering
Nourhan Kahwaji, Niklas Kotzian, Jasmin Melissa Prinz, Yaolin Pu, Jonas Kath, Samira Picht, Anna Luisa Hiller, Antonia M Klaas, Charlotte Maeve Dunne, Michael Launspach, Andriko Palmowski, Arnd Kleyer, David Simón, Dimitrios L. Wagner, Chantal Pichon, , Norman Michael Drzeniek
This study shows that unmodified mRNA can be used for CAR-T cell engineering without compromising function, eliminating the need for costly nucleoside modifications.
Molecular Therapy — Nucleic Acids · Jan 5, 2026Peer-reviewedBioengineering