Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure
Richard Gill, Daniel Lu, Ittai E. Eres, Jiamiao Lu, Jixin Cui, Zhongsheng Yu, Tracy Yamawaki, Hong Zhou, Baikang Pei, Junedh Amrute, Yen-Sin Ang, Songli Wang, Kory J. Lavine, Brandon L. Ason, Chi-Ming Li, Yi‐Hsiang Hsu
The paper identifies causal genes in heart disease GWAS loci by integrating Hi-C, chromatin accessibility, and transcriptomic data, revealing regulatory relationships in cardiac fibroblasts.
bioRxiv · Oct 8, 2024 · PreprintGenomics