Mechanical opening of the αE-catenin M-region gates afadin condensation in cardiomyocytes
Sabine Pokutta, Yerin Han, Korina I. Karpov, Jonathon A. Heier, William I. Weis, Adam V. Kwiatkowski
The paper shows that mechanical force opens the E-catenin M-region, enabling afadin condensate formation at high-load adherens junctions in cardiomyocytes.
bioRxiv · Sep 28, 2026 · PreprintCell Biology