Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1.
Sang Ah Yi, Liang Sun, Yi Rao, Alban Ordureau, Jason Stuart Lewis, Heeseon An
This study uses chemical probes to assess HMGCS1 inhibition, showing similar proteome effects to HMGCR inhibition and demonstrating efficacy in statin-resistant models.
bioRxiv · May 21, 2025 · PreprintBiochemistry