Yi Rao

This study identifies SNRK as essential for sleep regulation in Drosophila, showing that its loss causes severe sleep loss, which is rescued by neuronal SNRK expression or nicotinic acetylcholine receptor blockade.

The paper reexamines the sleep phenotype in Camk2a and Camk2b knockout mice, finding sleep reduction in Camk2a but not Camk2b mutants, and both participating in homeostatic sleep rebound.

The paper introduces conditional CCTomics tools to study chemical transmission in Drosophila, demonstrating their effectiveness by analyzing CCT gene expression in clock neurons and revealing an antagonistic relationship between CNMa-CNMaR and PDF-PDFR signaling.

This study identifies ppGpp as a molecule present in Drosophila that regulates sleep and starvation-induced sleep loss through the mesh1 gene and Dilp2 neurons.

This study identifies SIK3 T221 phosphorylation as an indicator and controller of sleep need, showing reduced sleep need in mutants and after sleep deprivation.

This study identifies calcineurin as a phosphatase that dephosphorylates SIK3 at specific sites, linking it to sleep regulation in mice.

This study identifies SLC6A17 as a glutamine transporter in synaptic vesicles, linking its dysfunction to intellectual disability through genetic and biochemical analyses.

The paper investigates creatine as a potential central neurotransmitter by analyzing its presence in synaptic vesicles, release patterns, and effects on neurons.

This study shows LKB1 is required for sleep in both Drosophila and mice, with reduced sleep observed in Lkb1 mutants across species.

This study identifies ppGpp in Drosophila and shows it regulates sleep through specific neurons.

The paper identifies SLC35D3 as a vesicular transporter for UDP-glucose through localization, proteomics, and metabolite profiling in neurons.

This study shows that post-reactivation new learning impairs episodic memory without disrupting reconsolidation, involving distinct processes for integration and impairment.