Author

Sang Ah Yi

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-7048-0252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Heeseon AniD· 2 shared Alban OrdureauiD· 1 shared Alison M. SchramiD· 1 shared Britta WeigeltiD· 1 shared Elisa de StanchinaiD· 1 shared Harika GundlapalliiD· 1 shared Hilla SolomoniD· 1 shared Jacqueline A.M. SmithiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Heeseon AnORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 14, 2026

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

Hilla Solomon, Radha Mukherjee, Yu Chi Yang…·Neal X. Rosen

This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.

DOI 10.64898/2026.02.12.705558

humanbulk RNA-seq

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BiochemistrybioRxivPreprintMay 21, 2025

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1.

Sang Ah Yi, Liang Sun, Yi Rao…·Heeseon An

This study uses chemical probes to assess HMGCS1 inhibition, showing similar proteome effects to HMGCR inhibition and demonstrating efficacy in statin-resistant models.

DOI 10.1101/2025.05.21.655359

humanproteomics

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