Author

Heeseon An

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-8518-4077Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Sang Ah YiiD· 2 shared Agnieszka KonopackaiD· 1 shared Alban OrdureauiD· 1 shared Alison M. SchramiD· 1 shared Andrew B. BenowitziD· 1 shared Aurore SaudemontiD· 1 shared Britta WeigeltiD· 1 shared C. Cameron Taylor· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Sang Ah YiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

Hilla Solomon, Radha Mukherjee, Yu Chi Yang, Julia Meredith, Alison M. Schram, Sang Ah Yi, Xiaoping Chen, Michael Tribuzio, Harika Gundlapalli, Justin Meyerowitz, Elisa de Stanchina, Britta Weigelt, Heeseon An, Simon T. Barry, Jacqueline A.M. Smith, , Neal X. Rosen

This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.

bioRxiv · Feb 14, 2026 · PreprintCancer Biology

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

Patrick J. Brennan, Rebecca E. Saunders, Mary Spanou, Sarah E. Singleton, M. Teresa Serafini, Liang Sun, Guillaume Heger, Agnieszka Konopacka, Ryan D. D. Beveridge, C. Cameron Taylor, Peter DePaola, Laurie Gordon, Shenaz B. Bunally, Aurore Saudemont, Andrew B. Benowitz, , Stuart J. Conway

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

ACS Chemical Biology · Nov 2, 2025Peer-reviewedBiochemistry

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1.

Sang Ah Yi, Liang Sun, Yi Rao, Alban Ordureau, Jason Stuart Lewis, Heeseon An

This study uses chemical probes to assess HMGCS1 inhibition, showing similar proteome effects to HMGCR inhibition and demonstrating efficacy in statin-resistant models.

bioRxiv · May 21, 2025 · PreprintBiochemistry