Jason Stuart Lewis

This study uses chemical probes to assess HMGCS1 inhibition, showing similar proteome effects to HMGCR inhibition and demonstrating efficacy in statin-resistant models.

This paper evaluates [225Ac]Ac-Macropa-Isatuximab as a targeted alpha therapy for CD38-positive hematological malignancies, showing significant tumor reduction and survival extension with minimal toxicity.

This paper compares 225Ac and 134Ce-labeled tracers in cancer models to assess their suitability as a theranostic pair, finding that 134Ce's PET imaging is limited by daughter nuclide redistribution.

This paper develops fluorescent imaging agents targeting NaV1.7 to improve nerve visualization during surgery, demonstrating effectiveness in non-human primates.