Author

Yicheng Guo

Aaron Diamond AIDS Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

David D. HoiD· 4 shared Aubree L. GordoniD· 3 shared Ian A. MellisiD· 3 shared Madeline Wu· 3 shared Qian WangiD· 3 shared Riccardo Valdez· 3 shared Anthony D. BoweniD· 2 shared Carmen GherasimiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

David D. HoORCID

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Author profile →

4 papers

Recent·Most cited

Do Existing COVID-19 Vaccines Need to Be Updated in 2025?

Ian A. Mellis, Madeline Wu, Qian Wang, Anthony D. Bowen, Carmen Gherasim, Riccardo Valdez, Jayesh Shah, Lawrence J. Purpura, Michael T. Yin, Aubree L. Gordon, Yicheng Guo, David D. Ho

This study assesses whether 2025 COVID-19 vaccines need updating by testing neutralizing antibody titers against emerging variants in individuals vaccinated with KP.2-based mRNA vaccines.

bioRxiv · May 2, 2025 · PreprintMicrobiology

Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC

Qian Wang, Yicheng Guo, Ian A. Mellis, Madeline Wu, Hiroshi Mohri, Carmen Gherasim, Riccardo Valdez, Lawrence J. Purpura, Michael T. Yin, Aubree L. Gordon, David D. Ho

This study evaluates the antibody evasion of SARS-CoV-2 subvariants KP.3.1.1 and XEC compared to their parental variants, finding increased resistance to neutralization by sera and antibodies targeting the spike protein.

Cell Reports · Apr 1, 2025Peer-reviewedMicrobiology

Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan

Nicholas C. Morano, Yicheng Guo, Jordan E. Becker, Zhiteng Li, Jian Yu, David D. Ho, Lawrence S. Shapiro, Peter D. Kwong

The paper reports the cryo-EM structure of H5N1 hemagglutinin showing an auto-glycan from N169 binds the receptor-binding site, highlighting auto-glycan recognition in zoonotic transmission.

Structure · Jan 29, 2025Peer-reviewedImmunology

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages

Qian Wang, Ian A. Mellis, Jerren Ho, Anthony D. Bowen, Theresa Kowalski-Dobson, Riccardo Valdez, Phinikoula S. Katsamba, Madeline Wu, Caitlin Lee, Lawrence S. Shapiro, Aubree Gordon, Yicheng Guo, David D. Ho, Lihong Liu

This study examines how recurrent spike mutations in SARS-CoV-2 JN.1 sublineages affect immune evasion, ACE2 affinity, and infectivity, identifying growth advantages in specific sublineages.

Emerging Microbes & Infections · Sep 11, 2024Peer-reviewedMicrobiology