Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes
Michael S. Poslusney, Qian Li, Ingrid P. Buchler, Yifang Huang, Liansheng Liu, Yaohui Zhu, Subhash Kulkarni, Gregory V. Carr, Adrienne C. DeBrosse, Noelle White, Diane E. Peters, James C. Barrow, Pankaj Jay Pasricha
This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience