Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia
Shuying Xu, Shumin Tan, Patricia Romanos, Jennifer L. Reedy, Yihan Zhang, Michael K. Mansour, Jatin M. Vyas, Joan C. Mecsas, Hongmei Mou, John M. Leong
This study identifies HXA3 as a driver of neutrophil transmigration and elastase release during pneumococcal infection, showing that blocking these processes reduces epithelial damage and bacteremia.
mBio · Aug 9, 2024Peer-reviewedMicrobiology