Shumin Tan

This study visualizes Mtb transcripts in infected lungs to show spatiotemporal gene expression differences related to lipid metabolism, environmental signals, and the ESX-1 system.

This study identifies Rv3839-Rv3840 as key regulators linking heme biosynthesis with Mtb adaptation to NO and iron limitation stress.

This study shows that STPK phosphorylation of DosR in Mtb reduces its transcriptional activity and alters its response to nitric oxide stress, highlighting a regulatory interaction between STPKs and TCSs.

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

This study shows that Mycobacterium tuberculosis adapts to acidic conditions by increasing growth-arrested cells, which enhance drug tolerance and survival.

This study differentiates Peromyscus leucopus bone marrow-derived macrophages and compares their responses to Borrelia burgdorferi and lipopolysaccharide with C57BL/6J macrophages, finding modest transcriptomic differences.

This study shows that cholesterol metabolism and potassium homeostasis are interconnected in Mycobacterium tuberculosis, with cholesterol modulating potassium transport and affecting bacterial growth.

This study identifies weakened airway epithelial junctions and increased neutrophil elastase release in aged mice as factors contributing to age-dependent bacteremia risk after pneumococcal pneumonia.

This study identifies HXA3 as a driver of neutrophil transmigration and elastase release during pneumococcal infection, showing that blocking these processes reduces epithelial damage and bacteremia.