The conserved NUS-1/DHDDS complex links N-glycosylation to lipid and lysosomal homeostasis in C. elegans
Meixi Gong, Yilin Du, Wentao Zhao, Lingfan Zhu, Changfeng Jia, Yuxiao Xie, Chen Liu, Wenfei Li, Pei Zhao, Zhe Zhang
This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.
bioRxiv · Dec 25, 2025 · PreprintCell Biology