Meixi Gong

This study shows that the LMD-3 mutation in C. elegans causes reproductive failure by disrupting lysosomal function and proteostasis, which can be reversed with vitamin B12 supplementation.

This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.

This study identifies LMD-3 as a regulator of proteostasis and reproductive capacity in C. elegans, showing its role in lysosomal function and the reversibility of fecundity decline with vitamin B12.