Author

Lingfan Zhu

Shandong UniversityORCID 0000-0002-9246-8852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Zhe ZhangiD· 4 shared Chuansen Yi· 3 shared Meng WuiD· 3 shared Changfeng JiaiD· 2 shared Chaomin SuniD· 2 shared Lei Qi· 2 shared Rikuan ZhengiD· 2 shared Wen‐Fei LiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiochemistry

Zhe ZhangORCID

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4 papers

Recent·Most cited

Long-form hibernation-promoting factor coordinates 100S assembly and translational repression

Meng Wu, Yuanjie Bai, Changbin Zhang, Chuansen Yi, Rikuan Zheng, Lei Qi, Lingfan Zhu, Zhe Zhang, Chaomin Sun, Wen‐Fei Li

This study identifies modular contributions of HPF domains to 100S assembly and translational repression using cryo-EM and functional analyses.

bioRxiv · Oct 5, 2026 · PreprintBiochemistry

A dual-factor complex governs archaeal ribosome hibernation by sensing energy status

Lingfan Zhu, Rikuan Zheng, Meng Wu, Xianshengjie Lang, Yueting Liang, Chuansen Yi, Qinqin Wang, Lei Qi, Jianyi Yang, Zhe Zhang, Xuben Hou, Jie Li, Chaomin Sun, Wenfei Li

This study identifies the Archaeal Ribosome regulatory Complex (ARC) as a dual-factor complex that modulates ribosome hibernation in response to energy status.

bioRxiv · Jan 19, 2026 · PreprintBiochemistry

The conserved NUS-1/DHDDS complex links N-glycosylation to lipid and lysosomal homeostasis in C. elegans

Meixi Gong, Yilin Du, Wentao Zhao, Lingfan Zhu, Changfeng Jia, Yuxiao Xie, Chen Liu, Wenfei Li, Pei Zhao, Zhe Zhang

This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.

bioRxiv · Dec 25, 2025 · PreprintCell Biology

Human ribosomes interactions reveal the binding landscape of neomycin

Meng Wu, Lingfan Zhu, Changfeng Jia, Xinyi Zhang, Zhongcheng Zhao, Hanhan Liu, Chuansen Yi, Shuangli Sun, Ke Liu, Zhe Zhang, Lei Guo, Xuben Hou, Wen‐Fei Li

The paper investigates neomycin's binding to human ribosomes using Cryo-EM and functional assays, revealing structural binding patterns that differ from cellular observations.

bioRxiv · Jul 22, 2025 · PreprintBiochemistry