Zhe Zhang

This study shows that the LMD-3 mutation in C. elegans causes reproductive failure by disrupting lysosomal function and proteostasis, which can be reversed with vitamin B12 supplementation.

This study identifies modular contributions of HPF domains to 100S assembly and translational repression using cryo-EM and functional analyses.

This paper presents an optimized E. coli cell-free protein synthesis system with fewer components and a simplified protocol, improving efficiency and accessibility for protein synthesis.

This study identifies the Archaeal Ribosome regulatory Complex (ARC) as a dual-factor complex that modulates ribosome hibernation in response to energy status.

This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.

This study identifies LMD-3 as a regulator of proteostasis and reproductive capacity in C. elegans, showing its role in lysosomal function and the reversibility of fecundity decline with vitamin B12.

The paper investigates neomycin's binding to human ribosomes using Cryo-EM and functional assays, revealing structural binding patterns that differ from cellular observations.