EZH1-dependent H3K27me1 is an adaptive chromatin barrier that limits DNMT inhibitor response in colorectal cancer
Alison A. Chomiak, Ashley K. Wiseman, Joel A. Hrit, Yanqing Liu, Stephanie Stransky, Ying Cui, Xiangqian Kong, Michael J. Topper, Stephen B. Baylin, Simone Sidoli, Rochelle L. Tiedemann, Scott B. Rothbart
This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology