ORP2 regulates free cholesterol accumulation in hepatocytes during MASH
Jin Wu, Yudi Zhao, Liwen Qiu, Qiaoli Chen, Xiaowei Wang, Jingwen Gu, Yan Liang, Yingjie Zhang, Hongyu Wang, Yang Liu, Xiaoqin Wu, Daiwen Chen, Feng‐Jung Chen, Mingming Gao, Hongyuan Yang
This study shows that ORP2 prevents free cholesterol accumulation in mouse liver, and its absence leads to severe MASH with cholesterol crystals.
Hepatology Communications · Jul 14, 2025Peer-reviewedCell Biology