Author

Feng‐Jung Chen

Fudan UniversityORCID 0000-0002-0041-003XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Hongyuan YangiD· 2 shared Jin WuiD· 2 shared Mingming GaoiD· 2 shared Peng LiiD· 2 shared Xiaoqin Wu· 2 shared Yang LiuiD· 2 shared Chengxin MaiD· 1 shared Chunmei ChangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

Hongyuan YangORCID

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3 papers

Recent·Most cited

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

Lingzhi Wu, Jianqin Wang, Ya Wang, Junhan Yang, Yuanhang Yao, Yonglun Wang, Dong Huang, Yating Hu, Xinxuan Xu, Renqian Wang, Wenjing Du, Yiting Shi, Quan Li, Lu Liu, Yuangang Zhu, , Xiao-Wei Chen

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Nature · Feb 25, 2026Peer-reviewedCell Biology

ORP2 regulates free cholesterol accumulation in hepatocytes during MASH

Jin Wu, Yudi Zhao, Liwen Qiu, Qiaoli Chen, Xiaowei Wang, Jingwen Gu, Yan Liang, Yingjie Zhang, Hongyu Wang, Yang Liu, Xiaoqin Wu, Daiwen Chen, Feng‐Jung Chen, Mingming Gao, Hongyuan Yang

This study shows that ORP2 prevents free cholesterol accumulation in mouse liver, and its absence leads to severe MASH with cholesterol crystals.

Hepatology Communications · Jul 14, 2025Peer-reviewedCell Biology

PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis

Jin Wu, Mingming Gao, Xiaoqin Wu, Yang Liu, Taiping Zhang, Yan Liang, Haixia Yang, Chengxin Ma, Youpi Ye, Chunmei Chang, Peng Li, Feng‐Jung Chen, Hongyuan Yang

The paper shows PI(4)P recruits CIDE proteins to form unilocular lipid droplets in adipogenesis and hepatic steatosis by interacting with ORP2/5 and PI4K2A.

Proceedings of the National Academy of Sciences · Jul 3, 2025Peer-reviewedCell Biology