Yang Liu

The paper develops a method to isolate autophagosomes from mice and uses proteomics to analyze cargo profiles in skeletal muscle during starvation and exercise, identifying distinct cargo selection patterns.

This study shows that ORP2 prevents free cholesterol accumulation in mouse liver, and its absence leads to severe MASH with cholesterol crystals.

The paper shows PI(4)P recruits CIDE proteins to form unilocular lipid droplets in adipogenesis and hepatic steatosis by interacting with ORP2/5 and PI4K2A.

The paper describes an ELISA-based assay for measuring AMPK activity, offering a simple, sensitive alternative to radioactive and commercial methods.