A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Lihua Zhao, Tian Xia, Yan Zhang, H. Eric Xu, Dehua Yang, Ming‐Wei Wang
This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.
Nature Communications · Apr 27, 2022Peer-reviewedMolecular Biology