Wenbo Feng

Lack of Ameliorative Effect of Chronic Oral Nicotine on Olfactory Dysfunction in Young Adult Presenilin-1/2 Double Knockout Mice of a Dementia Model

This study shows that chronic nicotine does not improve olfactory dysfunction in young adult Presenilin-1/2 double knockout mice, which model dementia, and highlights age-related decline in olfactory function.

A non-image-forming visual circuit mediates the innate fear of heights

This study identifies a non-image-forming visual circuit in mice that mediates innate fear of heights, independent of primary visual cortex processing.

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

The paper reports high-resolution structures of MC4R with agonists and reveals insights into ligand recognition and activation mechanisms.

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.