Spatial proximity sequencing maps developmental dynamics in the germinal center
Huili Wang, Junjie Xia, Peer Mohamed Suhail Mujibur Rahman, Bijentimala Keisham, Abinash Padhi, Yiyu Deng, Yan Li, Luke F. Vistain, Sarah Kim, Gabriel Mercado-Vasquez, Aly Azeem Khan, Marcus R. Clark, Savaş Tay
This paper introduces Sprox-seq, a multi-omic technique that maps protein interactions and mRNA in human germinal centers, revealing distinct B cell maturation pathways and spatially-enriched immune regulatory complexes.
Cell · Jul 16, 2026Peer-reviewedImmunology