Luke F. Vistain

This paper introduces Sprox-seq, a multi-omic technique that maps protein interactions and mRNA in human germinal centers, revealing distinct B cell maturation pathways and spatially-enriched immune regulatory complexes.

This study identifies PD-1's role in maintaining stem-like CD8+ T cells through TCR affinity regulation and signaling fine-tuning, showing its impact on immunotherapy efficacy.

The paper introduces a physical model and improved analysis methods for quantifying protein complexes from Prox-seq data, enhancing accuracy and robustness.