RARS1 integration into the multisynthetase complex is crucial for mammalian brain development
Samuel Protais Nyandwi, Rasangi Tennakoon, Qingyu Shi, Sofija Volkanoska, Danyon Harkins, Han Gao, Yong Bu, Colette Maya Macarios, Scott A. Yuzwa, Haissi Cui
This study shows that RARS1's integration into the multisynthetase complex is essential for normal brain development in mice, as its exclusion leads to developmental defects and gene dysregulation.
bioRxiv · Sep 8, 2025 · PreprintMolecular Biology