Qingyu Shi

Cell Surface Sialoglycan Engineering Through Exogenous mRNA

This paper develops an mRNA-based platform to transiently control sialoglycan biosynthesis on human cells by delivering sialyltransferase enzymes, showing increased surface presentation of specific sialoglycans with minimal off-target effects.

A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response

The paper investigates a disease-causing mutation in IARS1 that affects protein complex formation and the integrated stress response, leading to altered cellular stress responses.

Sialoglycans on human T cells attenuate death programs executed through the Fas pathway

This study shows that sialoglycans on human T cells reduce Fas receptor-mediated apoptosis but not other TNF receptor pathways.

A point mutation in the nuclear speckle protein and splicing factor SRRM2 is associated with amyotrophic lateral sclerosis and causes dysregulation of synapse-associated genes

This study identifies a point mutation in SRRM2 as a risk factor for ALS, showing it disrupts protein interactions and dysregulates synapse-related genes.

RARS1 integration into the multisynthetase complex is crucial for mammalian brain development

This study shows that RARS1's integration into the multisynthetase complex is essential for normal brain development in mice, as its exclusion leads to developmental defects and gene dysregulation.